| 年 |
論文 |
リンク |
| 2023 |
B. Jin, T. Ishikawa, M. Kashima, R. Komura, H. Hirata, T. Okada, and K. Mori. Activation of XBP1 but not ATF6a Rescues Heart Failure Induced by Persistent ER Stress in Medaka Fis, Life Sci. Alli., 2023, 13, e4738. |
Pubmed |
| 2023 |
T. Ikeda, T. Ishikawa, S. Ninagawa, T. Okada, M. Ono, and K. Mori. Proteomic Analysis of Fatty Liver Induced by Starvation of Medaka Fish Larvae., Cell Struc. Func., 2023, 48, 123-133. |
Pubmed |
| 2023 |
S. Saito and K. Mori. Detection and Quantification of Calcium Ions in the Endoplasmic Reticulum and Cytoplasm of Cul, Bioprotocol, 2023, 13, e4738. |
Pubmed |
| 2023 |
T. Tanaka, D.T. Nguyen, N. Kwankaew, M. Sumizono, R. Shinoda, H. Ishii, M. Takarada-Iemata, T. Hattori, S. Oyadomari, N. Kato, K. Mori & O. Hori. ATF6β deficiency elicits anxiety-like behavior and hyperactivity under stress conditions., Neurochem. Res., 2023, 48, 2175-2186. |
Pubmed |
| 2023 |
S. Jin, B. Jin, T. Ishikawa, S. Ninagawa, T. Okada, S. Koyasu, H. Harada, and K. Mori. Loss of ATF6a in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6b but by, Mol. Biol. Cell, 2023, 34:ar20. |
Pubmed |
| 2022 |
S. Saito, T. Ishikawa, S. Ninagawa, T. Okada and K. Mori. A Motor Neuron Disease-associated Mutation Produces Non-glycosylated Seipin that Induces ER Stress a, eLife, 2022, 11: e74805. |
Pubmed |
| 2021 |
G George, S. Ninagawa, H. Yagi, J. Furukawa, N. Hashii, A. Ishii-Watabe, Y. Deng, K. Matsushita, T. Ishikawa, Y. P. Mamahit, Y. Maki, Y. Kajihara, K. Kato, T. Okada and K. Mori. Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian, eLife, 2021, 10, e70357. |
Pubmed |
| 2021 |
D. T. Nguyen, T. M. Le, T. Hattori, M. Takarada-Iemata, H. Ishii, J. Roboon, T. Tamatani, T. Kannon, K. Hosomichi, A. Tajima, S. Taniuchi, M. Miyake, S. Oyadomari, T. Tanaka, N. Kato, S. Saito, K. Mori, O. Hori. The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and, Sci. Rep., 2021, 11, 13086. |
Pubmed |
| 2021 |
K. Tabata, M. Arakawa, K. Ishida, M. Kobayashi, A. Nara, T. Sugimoto, T. Okada, K. Mori, and E. Morita. Endoplasmic reticulum-associated degradation controls virus protein homeostasis that is required for, J. Virol., 2021, 95, e0223420. |
Pubmed |
| 2020 |
S. Ninagawa, S. Tada, M. Okumura, K. Inoguchi, M. Kinoshita, S. Kanemura, K. Imami, H. Umezawa, T. Ishikawa, R. B. Mackin, S. Torii, Y. Ishihama, K. Inaba, T. Anazawa, T. Nagamine and K. Mori. Antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum account for, eLife, 2020, 9, e60970. |
Pubmed |
| 2020 |
G. George, S. Ninagawa, H. Yagi, T. Saito, T. Ishikawa, T. Sakuma, T. Yamamoto, K. Imami, Y. Ishihama, K. Kato, T. Okada and K. Mori. EDEM2 Stably Disulfide-bonded to TXNDC11 Catalyzes the First Mannose Trimming Step in Mammalian Glyc, eLife, 2020, 9, e53455. |
Pubmed |
| 2020 |
B. Jin, T. Ishikawa, M. Taniguchi, S. Ninagawa, T. Okada, S. Kagaya and K. Mori. Development of a rapid in vivo assay to evaluate the efficacy of IRE1-specific inhibitors of the un, Cell Struct. Funct., 2020, 45, 23-31. |
Pubmed |
| 2020 |
H. Koba, S. Jin, N. Imada, T. Ishikawa, S. Ninagawa, T. Okada, T. Sakuma, T. Yamamoto and K. Mori. Reinvestigation of disulfide-bonded oligomeric forms of the unfolded protein response transduc, Cell Struct. Funct., 2020, 45, 9-21. |
Pubmed |
| 2019 |
T.-M. Jao, M. Nangaku, C.-H. Wu, M. Sugahara, H. Saito, H. Maekawa, Y. Ishimoto, M. Aoe, T. Inoue, T. Tanaka, B. Staels, K. Mori, and R. Inagi. ATF6α and PPARα crosstalk provides new insights into lipotoxicity-induced tubulointerstitial f, Kidney Int., 2019, 95, 577-589. |
Pubmed |
| 2019 |
L.H.W. Kung, L. Mullan, J. Soul, P. Wang, K. Mori, J.F. Bateman, M.D. Briggs, R.P. Boot-Handford. Cartilage endoplasmic reticulum stress may influence the onset but not the progression of expe, Arthritis Res. Ther., 2019, 21, 206. |
Pubmed |
| 2018 |
T.Ishikawa, S. Ansai, M. Kinoshita and K. Mori. A Collection of Transgenic Medaka Strains for Efficient Site-directed Transgenesis Mediated by, G3: Genes, Genomes, Genetics, 2018, 8, 2585-2593. |
Pubmed |
| 2018 |
T. Sasaki, A. Kuboyama, M. Mita, S. Murata, M. Shimizu, J. Inoue, K. Mori, and R. Sato. The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice., J. Biol. Chem., 2018, 293, 10322-10332. |
Pubmed |
| 2018 |
M. Forouhan, K. Mori, and R.P. Boot-Handford. Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in col, Matrix Biol., 2018, 70, 50-71. |
Pubmed |
| 2017 |
T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara, T. Todo, E. Aoyama, M. Takigawa, A. Harada and K. Mori. UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Sp, J. Cell Biol., 2017, 216, 1761-1774. |
Pubmed |
| 2017 |
T. Ishikawa, M. Kashima, A. J. Nagano, T. Ishikawa-Fujiwara, Y. Kamei, T. Todo, and K. Mori. Unfolded Protein Response Transducer IRE1-mediated Signaling Independent of XBP1 mRNA Splicing, eLife, 2017, e26845. |
Pubmed |
| 2017 |
T. Sugimoto, S. Ninagawa, S. Yamano, T. Ishikawa, T. Okada, S. Takeda and K. Mori. SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated, Cell Struct. Funct., 2017, 42, 81-94. |
Pubmed |
| 2016 |
S. Ninagawa and K. Mori. Trypsin sensitivity assay to study the folding status of proteins., Bio-protocol, 2016, e1953. |
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| 2016 |
S. Ninagawa and K. Mori. PNGase sensitivity assay to study the folding status of proteins., Bio-protocol, 2016, e1952. |
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| 2016 |
N. J. Martinez, G. Rai, A. Yasgar, W. A. Lea, H. Sun, Y. Wang, D. K. Luci, S.-M. Yang, K. Nishihara, S. Takeda, Mohiuddin, I. Earnshaw, T. Okada, K. Mori, K. Wilson, G. J. Riggins, M. Xia, M. Grimaldi, A. Jadhav, D. J. Maloney, and A. Simeonov. A high-throughput screen identifies 2,9-diazaspiro[5.5]undecanes as inducers of the endoplasmi, PLoS One, 2016, |
Pubmed |
| 2016 |
H. M. Ta, T. M. Le, H. Ishii, M. Takarada-Iemata, T. Hattori, K. Hashida, Y. Yamamoto, K. Mori, R. Takahashi, Y. Kitao, and O. Hori. Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental aut, J. Neurochem., 2016, 139, 1124-1137. |
Pubmed |
| 2016 |
D. Kezuka, M. Takarada-Iemata, T. Hattori, K. Mori, R. Takahashi, Y. Kitao, and O. Hori. Deletion of Atf6α enhances kainate-induced neuronal death in mice., Neurochem. Int., 2016, 92, 67-74. |
Pubmed |
| 2016 |
W. Lu, D. Hagiwara, Y. Morishita, M. Tochiya, Y. Azuma, H. Suga, M. Goto, R. Banno, Y. Sugimura, S. Oyadomari, K. Mori, and H. Arima. . Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice., Neurosci Lett., 2016, 612, 199-203. |
Pubmed |
| 2015 |
S. Ninagawa, T. Okada, Y. Sumitomo, S. Horimoto, T. Sugimoto, T. Ishikawa, S. Takeda, T. Yamamoto, T. Suzuki, Y. Kamiya, K. Kato and K. Mori. Forcible Destruction of Severely Misfolded Mammalian Glycoproteins by the Non-glycoprotein ERAD Pathway., J. Cell Biol., 2015, 211, 775-784. |
Pubmed |
| 2015 |
T. Koga, M. A. Suico, S. Shimasaki, E. Watanabe, Y. Kai, K. Koyama, K. Omachi, S. Morino-Koga, T. Sato, T. Shuto, K. Mori, S. Hino, M. Nakao, H. Kai. Endoplasmic reticulum stress induces SIRT1 expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury., J Biol. Chem., 2015, 290, 30366-30374. |
Pubmed |
| 2015 |
L. Zeng, Y. Li, J. Yang, G. Wang, A. Margariti, Q. Xiao, A. Zampetaki, X. Yin, M. Mayr, K. Mori, W. Wang, Y. Hu, and Q. Xu. The XBP1-deficiency abrogates neointimal lesion of injured vessels via crosstalk with PDGF signalling., Arterioscler. Thromb. Vasc. Biol., 2015, 35, 2134-2144. |
Pubmed |
| 2015 |
A. Nogalska, C. D’Agostino, W. K. Engel, M. Cacciottolo, S. Asada, K. Mori, and V. Askanas. Activation of the unfolded protein response in sporadic inclusion-body myositis but not in hereditary GNE-inclusion-body myopathy., J. Neuropathol. Exp. Neurol., 2015, 74, 538-546. |
Pubmed |
| 2015 |
A. Yoshikawa, T. Kamide, K. Hashida, H. M. Ta, Y. Inahata, M. Takarada-Iemata, T. Hattori, K. Mori, R. Takahashi, T. Matsuyama, Y. Hayashi, Y. Kitao, and O. Hori. Deletion of Atf6α impairs astroglial activation and enhances neuronal death after brain ischemia in mice., J. Neurochem., 2015, 132, 342-353. |
Pubmed |
| 2014 |
S. Ninagawa, T. Okada, Y. Sumitomo, Y. Kamiya, K. Kato, S. Horimoto, T. Ishikawa, S. Takeda, T. Sakuma, T. Yamamoto and K. Mori. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step., J. Cell Biol., 2014, 206, 347-356. |
Pubmed |
| 2014 |
Y. Azuma, D. Hagiwara, W. Lu, Y. Morishita, H. Suga, M. Goto, R. Banno, Y. Sugimura, S. Oyadomari, K. Mori, A. Shiota, N. Asai, M. Takahashi, Y. Oiso and H. Arima. Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice., Endocrinol., 2014, 155, 4905-4914. |
Pubmed |
| 2013 |
S. Horimoto, S. Ninagawa, T. Okada, H. Koba, T. Sugimoto, Y. Kamiya, K. Kato, S. Takeda and K. Mori. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein., J. Biol. Chem., 2013, 288, 31517-31527. |
Pubmed |
| 2013 |
R. Ozasa, T. Okada, S. Nadanaka, T. Nagamine, A. Zyryanova, H. Harding, D. Ron and K. Mori. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation., Cell Struct. Funct., 2013, 38, 183-195. |
Pubmed |
| 2013 |
T. Ishikawa, T. Okada, T. Ishikawa-Fujiwara, T. Todo, Y. Kamei, S. Shigenobu, M. Tanaka, T. L. Saito, J. Yoshimura, S. Morishita, A. Toyoda, Y. Sakaki, Y. Taniguchi, S. Takeda and K. Mori. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish, Mol. Biol. Cell, 2013, 24, 1387-1395. |
Pubmed |
| 2013 |
L. Zeng, Q. Xiao, M. Chen, A. Margariti, D. Martin, A. Ivetic, H. Xu, J. Mason, W. Wang, G. Cockerill, K. Mori, Y.-S. Li, S. Chien, Y. Hu, and Q. Xu. VEGF-activated XBP1 splicing in endothelial cells is crucial for angiogenesis., Circulation, 2013, 127, 1712-1722. |
Pubmed |
| 2012 |
K. Hashida, Y. Kitao, H. Sudo, Y. Awa, K. Mori, R. Takahashi, M. Iinuma, O. Hori. ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson’s disease., PLoS One, 2012, 7, e47950. |
Pubmed |
| 2012 |
J. M. Lynch, M. Maillet, D. Vanhoutte, A. Schloemer, M. A. Sargent, N. S. Blair, K. A. Lynch, T. Okada, B. J. Aronow, H. Osinska, R. Prywes, J. N. Lorenz, K. Mori, J. Lawler, J. Robbins and J. D. Molkentin. A thrombospondin-dependent pathway for a protective ER stress response, Cell, 2012, 149, 1257-1268. |
Pubmed |
| 2012 |
P. Gade, G. Ramachandran, U.B. Maachani, M.A. Rizzo, T. Okada, R. Prywes, A.S. Cross. K. Mori and D. J. Kalvakolanu. A novel IFN-γ-stimulated ATF6/C/EBP-β signaling pathway critical for the expression of DAPK 1 and induction of autophagy., Proc. Natl. Acad. Sci. USA, 2012, 109, 10316-10321. |
Pubmed |
| 2012 |
I. V. Aragon, R. A. Barrington, S. Jackowski, K. Mori and J. W. Brewer. The Specialized Unfolded Protein Response of B Lymphocytes: ATF6α-Independent Development of Antibody-Secreting B cells., Mol. Immunol., 2012, 51, 347-355. |
Pubmed |
| 2012 |
M. Usui, S. Yamaguchi, Y. Tanji, R. Tominaga, Y. Ishigaki, M. Fukumoto, H. Katagiri, K. Mori, Y. Oka and H. Ishihara. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance., Metabol., 2012, 61, 1118-1128. |
Pubmed |
| 2012 |
P. Menu, A. Mayor, R. Zhou, A. Tardivel, H. Ichijo, K. Mori and J. Tschopp. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway., Cell Death Disease, 2012, 3, e261 |
Pubmed |
| 2011 |
T. Ishikawa, Y. Taniguchi, T. Okada, S. Takeda and K. Mori. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in medaka fish., Cell Struc. Func., 2011, 36, 247-259. |
Pubmed |
| 2011 |
S. Ninagawa, T. Okada, S. Takeda and K. Mori. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line., Cell Struc. Func., 2011, 36, 187-195. |
Pubmed |
| 2011 |
N. Egawa, K. Yamamoto, H. Inoue, R. Hikawa, K. Nishi, K. Mori and R. Takahashi. The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death., J. Biol. Chem., 2011, 286, 7947-7957. |
Pubmed |
| 2011 |
Y. Sato, S. Nadanaka, T. Okada, K. Okawa and K. Mori. Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus., Cell Struc. Func., 2011, 36, 35-47. |
Pubmed |
| 2010 |
S. Shimasaki, T. Koga, T. Shuto, MA. Suico, T. Sato, K. Watanabe, S. Morino-Koga, M. Taura, S. Okada, K. Mori and H. Kai. Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells., Biochem. Biophys. Res. Commun., 2010, 402, 235-240. |
Pubmed |
| 2010 |
K. Yamamoto, K. Takahara, S. Oyadomari, T. Okada, T. Sato, A. Harada and K. Mori. Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress, Mol. Biol. Cell, 2010, 21, 2975-2986. |
Pubmed |
| 2009 |
M. Irisawa, J. Inoue, N. Ozawa, K. Mori, and R. Sato. The sterol-sensing ER membrane protein TRC8 hampers ER-to-Golgi transport of SREBP-2/SCAP and reduces SREBP-2 cleavage, J. Biol. Chem., 2009, 284, 28995-29004. |
Pubmed |
| 2009 |
A. Uemura, M. Oku, K. Mori, and H. Yoshida. Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during mammalian unfolded protein response, J. Cell Sci., 2009, 122, 2877-2886. |
Pubmed |
| 2009 |
L. Zeng, A. Zampetaki, A. Margariti, A. E. Pepe, S. Alam, D. Martin, Q. Xiao, W. Wang, Z. Jin, G. Cockerill, K. Mori, Y. J. Li, Y. Hu, S. Chien and Q. Xu. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow, Proc. Natl. Acad. Sci. USA, 2009, 106, 8326-8331. |
Pubmed |
| 2009 |
A. Tanimura, T. Yujiri, Y. Tanaka, M. Hatanaka, N. Mitani, Y. Nakamura, K. Mori and Y. Tanizawa. The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells, Leukemia Res., 2009, 33, 924-928. |
Pubmed |
| 2009 |
H. Yoshida, A. Uemura and K. Mori. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation, Cell Struc. Func., 2009, 34, 1-10. |
Pubmed |
| 2009 |
T. Uemura, T. Sato, T. Aoki, A. Yamamoto, T. Okada, R. Hirai, R. Harada, K. Mori, M. Tagaya, and A. Harada. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival, Mol. Cell. Biol., 2009, 29, 1869-1881. |
Pubmed |
| 2008 |
K. Yamamoto, N. Suzuki, T. Wada, T. Okada, H. Yoshida, R. J. Kaufman and K. Mori. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds, J. Biochem., 2008, 144, 477-486 |
Pubmed |
| 2008 |
Y. Adachi, K. Yamamoto, T. Okada, H. Yoshida, A. Harada and K. Mori. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum, Cell Struc. Func., 2008, 33, 75-89. |
Pubmed |
| 2007 |
K. Yamamoto, T. Sato, T. Matsui, M. Sato, T. Okada, H. Yoshida, A. Harada and K. Mori. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1, Dev. Cell, 2007, 13, 365-376. |
Pubmed |
| 2007 |
S. Nadanaka, T. Okada, H. Yoshida, and K. Mori. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress, Mol. Cell. Biol., 2007, 27, 1027-1043. |
Pubmed |
| 2007 |
Y. Tsukumo, A. Tomida, O. Kitahara, Y. Nakamura, S. Asada, K. Mori and T. Tsuruno. Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation, J. Biol. Chem., 2007, 282, 29264-29272. |
Pubmed |
| 2006 |
H. Yoshida, S. Nadanaka, R. Sato and K. Mori. XBP1 is critical to protect cells from endoplasmic reticulum stress: Evidence from site-2 protease-deficient Chinese hamster ovary cells, Cell Struc. Funct., 2006, 31, 117-125. |
Pubmed |
| 2006 |
M. Arai, N. Kondoh, N. Imazeki, A. Hada, K. Hatsuse, F. Kimura, O. Matsubara, K. Mori, T. Wakatsuki, M. Yamamoto. Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis, FEBS lett., 2006, 580, 184-190. |
Pubmed |
| 2006 |
S. Nadanaka, H. Yoshida and K. Mori. Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation, Cell Struc. Func., 2006, 31, 127-134. |
Pubmed |
| 2006 |
H. Yoshida, M. Oku, M. Suzuki and K. Mori. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response, J. Cell Biol., 2006, 172, 565-575. |
Pubmed |
| 2006 |
K. Zu, T. Bihani, A.Lin,Y.-M. Park, K. Mori, and C. Ip. Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells, Oncogene, 2006, 25, 546-554. |
Pubmed |
| 2006 |
Y. Oda, T. Okada, H. Yoshida, R. J. Kaufman, K. Nagata and K. Mori. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation, J. Cell Biol., 2006, 172, 383-393. |
Pubmed |
| 2006 |
S. Nadanaka, H. Yoshida, R. Sato and K. Mori. Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells, Cell Struc. Funct., 2006, 31, 109-116. |
Pubmed |
| 2006 |
D.T. Rutkowski, S.M. Arnold, C.N. Miller, J. Wu, J. Li, K.M. Gunnison, K. Mori, A.A. Sadighi Akha, D. Raden and R.J. Kaufman. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins, PLoS Biol., 2006, 4, 2024-2041. |
Pubmed |
| 2005 |
X. Xue, J.H. Piao, A. Nakajima, S. Sakon-Komazawa, Y. Kojima, K. Mori, H. Yagita, K. Okumura, H. Harding, H. Nakano. Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα, J. Biol. Chem., 2005, 280, 33917-33925. |
Pubmed |
| 2005 |
J. Ramos-Castaeda, Y.-N. Park, M. Liu, K. Hauser, H. Rudolph, G.E. Shull, M. F. Jonkman, K. Mori, S. Ikeda, H. Ogawa, and P. Arvan. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress, J. Biol. Chem., 2005, 280, 9467-9473. |
Pubmed |
| 2005 |
Z.-M. Huang, T. Tan, H. Yoshida, K. Mori, Y. Ma, and T.S.B. Yen. Activation of Hepatitis B Virus S promoter by a cell-type restricted IRE1-dependent pathway induced by endoplasmic reticulum stress, Mol. Cell. Biol., 2005, 25, 7522-7533. |
Pubmed |
| 2004 |
M. M. Khan, T. Nomura, T. Chiba, K. Tanaka, H. Yoshida, K. Mori, and S. Ishii. The fusion oncoprotein PML-RARa induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress, J. Biol. Chem., 2004, 279, 11814-11824 |
Pubmed |
| 2004 |
L. Zeng, M. Lu, K. Mori, S. Luo, A.S. Lee, Y. Zhu, and J. Y-J. Shyy. Activating transcription factor 6 modulates the sterol regulatory element binding protein-mediated lipogenesis, EMBO J., 2004, 23, 950-958. |
Pubmed |
| 2004 |
J. Nozaki, H. Kubota, H. Yoshida, M. Naitoh, J. Goji, T. Yoshinaga, K. Mori, A. Koizumi, and K. Nagata. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic β cells, Genes Cells, 2004, 9, 261-270. |
Pubmed |
| 2004 |
K. D. Tardif, K. Mori, R. J. Kaufman, and A. Siddiqui. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response, J. Biol. Chem., 2004, 279, 17158-17164. |
Pubmed |
| 2004 |
M. Flores-Diaz, J.-C. Higuita, I. Florin, T. Okada, P. Pollesello, T. Bergman, M. Thelestam, K. Mori, and A. Alape-Giron. A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen regulated proteins independent of the endoplasmic reticulum stress elements, J. Biol. Chem., 2004, 279, 21724-21731. |
Pubmed |
| 2004 |
K. E. Gunn, N. M. Gifford, K. Mori, and J. W. Brewer. A role for the unfolded protein response in optimizing antibody secretion, Mol. Immunol., 2004, 41, 919-927. |
Pubmed |
| 2004 |
K. Yamamoto, H. Yoshida, K. Kokame, R. J. Kaufman, and K. Mori. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II, J. Biochem., 2004, 136, 343-350 |
Pubmed |
| 2004 |
L. Romero-Ramirez, H. Cao, D. Nelson, E. Hammond, A.-H. Lee, H. Yoshida, K. Mori, L. H. Glimcher, N. C. Denko, A. J. Giaccia, Q.-T. Le, and A. C. Koong. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth, Cancer Res., 2004, 64, 5943-5947. |
Pubmed |
| 2004 |
R. Sriburi, S. Jackowski, K. Mori, and J. W. Brewer. XBP1: a link between the unfolded protein response, lipid biosynthesis and biogenesis of the endoplasmic reticulum, J. Cell Biol., 2004, 167, 35-41. |
Pubmed |
| 2004 |
N. Ogawa and K. Mori. Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein response, Genes Cells, 2004, 9, 95-104. |
Pubmed |
| 2004 |
S. Nadanaka, H. Yoshida, F. Kano, M. Murata, and K. Mori. Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum, Mol. Biol. Cell, 2004, 15, 2537-2548. |
Pubmed |
| 2003 |
R. Kumar, G. S. Krause, H. Yoshida, K. Mori, and D. J. DeGracia. Dysfunction of the unfolded protein response during global brain ischemia and reperfusion, J. Cereb. Blood Flow Metab., 2003, 23, 462-471. |
Pubmed |
| 2003 |
H. Yoshida, T. Matsui, N. Hosokawa, R. J. Kaufman, K. Nagata, and K. Mori. A time-dependent phase shift in the mammalian unfolded protein response, Dev. Cell, 2003, 4, 265-271. |
Pubmed |
| 2003 |
B. Nyfeler, O. Nufer, T. Matsui, K. Mori and H.-P. Hauri. The cargo receptor ERGIC-53 is a target of the unfolded protein response, Biochem. Biophys. Res. Commun., 2003, 304, 599-604. |
Pubmed |
| 2003 |
M. Shuda, N. Kondoh, N. Imazeki, K. Tanaka, T. Okada, K. Mori, A. Hada, M. Arai, T. Wakatsuki, O. Matsubara, N. Yamamoto, M. Yamamoto. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis, J. Hepatol., 2003, 38, 605-614. |
Pubmed |
| 2003 |
T. Okada, K. Haze, S. Nadanaka, H. Yoshida, N. G. Seidah, Y. Hirano, R. Sato, M. Negishi and K. Mori. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6, J. Biol. Chem., 2003, 278, 31024-31032 |
Pubmed |
| 2002 |
T. Gotoh, S. Oyadomari, K. Mori, and M. Mori. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP, J. Biol. Chem., 2002, 277, 12343-12350. |
Pubmed |
| 2002 |
K. Lee, W. Tirasophon, X. Shen, M. Michalak, R. Prywes, T. Okada, H.Yoshida, K. Mori, and R. J. Kaufman. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response, Genes Dev., 2002, 16, 452-466. |
Pubmed |
| 2002 |
K. D. Tardif, K. Mori, and A. Siddiqui. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway, J. Virol., 2002, 76, 7453-7459. |
Pubmed |
| 2002 |
T. Okada, H. Yoshida, R. Akazawa, M. Negishi, and K. Mori. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response, Biochem. J., 2002, 366, 585-594. |
Pubmed |
| 2001 |
H.Yoshida, T.Matsui, A.Yamamoto, T.Okada, and K.Mori. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor, Cell, 2001, 107, 881-891. |
Pubmed |
| 2001 |
K. Haze, T. Okada, H. Yoshida, H. Yanagi, T. Yura, M. Negishi, and K. Mori. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response, Biochem. J., 2001, 355, 19-28. |
Pubmed |
| 2001 |
H. Yoshida, T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi and K. Mori. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6a and 6b that activates the mammalian unfolded protein response, Mol. Cell. Biol., 2001, 21, 1239-1248. |
Pubmed |
| 2001 |
Katayama, T., Imaizumi, K., Honda, A., Yoneda, T., Kudo, T., Takeda, M., Mori K., Rozmahel, R., Fraser, P., St George-Hyslop, P.,and Tohyama, M. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer’s disease-linked presenilin 1 mutations, J. Biol. Chem., 2001, 276, 43446-43454. |
Pubmed |
| 2001 |
X. Shen, R.E. Ellis, K. Lee, C.-Y. Liu, K. Yang, A. Solomon, H. Yoshida, R. Morimoto, D.M. Kurnit, K. Mori, and R.J. Kaufman. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development, Cell, 2001, 107, 893-903. |
Pubmed |
| 2000 |
K. Mori, N. Ogawa, T. Kawahara, H. Yanagi, T. Yura. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response, Proc. Natl. Acad. Sci. USA, 2000, 97, 4660-4665. |
Pubmed |
| 2000 |
H. Yoshida, T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi and K. Mori. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response, Mol. Cell. Biol., 2000, 20, 6755-6767. |
Pubmed |
| 1999 |
K. Haze, H. Yoshida, H. Yanagi, T. Yura, and K. Mori. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress, Mol. Biol. Cell, 1999, 10, 3787-3799. |
Pubmed |
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