発表論文

英文総説 (5)

論文 リンク
2015 K. Mori. The unfolded protein response: the dawn of a new field., Proc. Jpn Acad. Ser. B Phys. Biol. Sci., 2015, 91, 469-80. Pubmed
2010 K. Mori. Retrospective - Divest yourself of a preconceived idea: Transcription factor ATF6 is not a soluble protein!, Mol. Biol. Cell, 2010, 21, 1435-1438. Pubmed
2009 K. Mori. Signalling pathways in the unfolded protein response: development from yeast to mammals, J. Biochem., 2009, 146, 743-750. Pubmed
2003 K. Mori. Frame switch splicing and regulated intramembrane proteolysis: key words to understand the unfolded protein response, Traffic, 2003, 4, 519-528. Pubmed
2000 K. Mori. Tripartite management of unfolded proteins in the endoplasmic reticulum, Cell, 2000, 101, 451-454. Pubmed

原著論文 (96)

論文 リンク
2019 T.-M. Jao, M. Nangaku, C.-H. Wu, M. Sugahara, H. Saito, H. Maekawa, Y. Ishimoto, M. Aoe, T. Inoue, T. Tanaka, B. Staels, K. Mori, and R. Inagi. ATF6α and PPARα crosstalk provides new insights into lipotoxicity-induced tubulointerstitial f, Kidney Int., 2019, 95, 577-589. Pubmed
2019 L.H.W. Kung, L. Mullan, J. Soul, P. Wang, K. Mori, J.F. Bateman, M.D. Briggs, R.P. Boot-Handford. Cartilage endoplasmic reticulum stress may influence the onset but not the progression of expe, Arthritis Res. Ther., 2019, 21, 206. Pubmed
2018 T.Ishikawa, S. Ansai, M. Kinoshita and K. Mori. A Collection of Transgenic Medaka Strains for Efficient Site-directed Transgenesis Mediated by, G3: Genes, Genomes, Genetics, 2018, 8, 2585-2593. Pubmed
2018 T. Sasaki, A. Kuboyama, M. Mita, S. Murata, M. Shimizu, J. Inoue, K. Mori, and R. Sato. The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice., J. Biol. Chem., 2018, 293, 10322-10332. Pubmed
2018 M. Forouhan, K. Mori, and R.P. Boot-Handford. Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in col, Matrix Biol., 2018, 70, 50-71. Pubmed
2017 T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara, T. Todo, E. Aoyama, M. Takigawa, A. Harada and K. Mori. UPR Transducer BBF2H7 Allows Export of Type II Collagen in a Cargo- and Developmental Stage-Sp, J. Cell Biol., 2017, 216, 1761-1774. Pubmed
2017 T. Ishikawa, M. Kashima, A. J. Nagano, T. Ishikawa-Fujiwara, Y. Kamei, T. Todo, and K. Mori. Unfolded Protein Response Transducer IRE1-mediated Signaling Independent of XBP1 mRNA Splicing, eLife, 2017, e26845. Pubmed
2017 T. Sugimoto, S. Ninagawa, S. Yamano, T. Ishikawa, T. Okada, S. Takeda and K. Mori. SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated, Cell Struct. Funct., 2017, 42, 81-94. Pubmed
2016 S. Ninagawa and K. Mori. Trypsin sensitivity assay to study the folding status of proteins., Bio-protocol, 2016, e1953.
2016 S. Ninagawa and K. Mori. PNGase sensitivity assay to study the folding status of proteins., Bio-protocol, 2016, e1952.
2016 N. J. Martinez, G. Rai, A. Yasgar, W. A. Lea, H. Sun, Y. Wang, D. K. Luci, S.-M. Yang, K. Nishihara, S. Takeda, Mohiuddin, I. Earnshaw, T. Okada, K. Mori, K. Wilson, G. J. Riggins, M. Xia, M. Grimaldi, A. Jadhav, D. J. Maloney, and A. Simeonov. A high-throughput screen identifies 2,9-diazaspiro[5.5]undecanes as inducers of the endoplasmi, PLoS One, 2016, Pubmed
2016 H. M. Ta, T. M. Le, H. Ishii, M. Takarada-Iemata, T. Hattori, K. Hashida, Y. Yamamoto, K. Mori, R. Takahashi, Y. Kitao, and O. Hori. Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental aut, J. Neurochem., 2016, 139, 1124-1137. Pubmed
2016 D. Kezuka, M. Takarada-Iemata, T. Hattori, K. Mori, R. Takahashi, Y. Kitao, and O. Hori. Deletion of Atf6α enhances kainate-induced neuronal death in mice., Neurochem. Int., 2016, 92, 67-74. Pubmed
2016 W. Lu, D. Hagiwara, Y. Morishita, M. Tochiya, Y. Azuma, H. Suga, M. Goto, R. Banno, Y. Sugimura, S. Oyadomari, K. Mori, and H. Arima. . Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice., Neurosci Lett., 2016, 612, 199-203. Pubmed
2015 S. Ninagawa, T. Okada, Y. Sumitomo, S. Horimoto, T. Sugimoto, T. Ishikawa, S. Takeda, T. Yamamoto, T. Suzuki, Y. Kamiya, K. Kato and K. Mori. Forcible Destruction of Severely Misfolded Mammalian Glycoproteins by the Non-glycoprotein ERAD Pathway., J. Cell Biol., 2015, 211, 775-784. Pubmed
2015 T. Koga, M. A. Suico, S. Shimasaki, E. Watanabe, Y. Kai, K. Koyama, K. Omachi, S. Morino-Koga, T. Sato, T. Shuto, K. Mori, S. Hino, M. Nakao, H. Kai. Endoplasmic reticulum stress induces SIRT1 expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury., J Biol. Chem., 2015, 290, 30366-30374. Pubmed
2015 L. Zeng, Y. Li, J. Yang, G. Wang, A. Margariti, Q. Xiao, A. Zampetaki, X. Yin, M. Mayr, K. Mori, W. Wang, Y. Hu, and Q. Xu. The XBP1-deficiency abrogates neointimal lesion of injured vessels via crosstalk with PDGF signalling., Arterioscler. Thromb. Vasc. Biol., 2015, 35, 2134-2144. Pubmed
2015 A. Nogalska, C. D’Agostino, W. K. Engel, M. Cacciottolo, S. Asada, K. Mori, and V. Askanas. Activation of the unfolded protein response in sporadic inclusion-body myositis but not in hereditary GNE-inclusion-body myopathy., J. Neuropathol. Exp. Neurol., 2015, 74, 538-546. Pubmed
2015 A. Yoshikawa, T. Kamide, K. Hashida, H. M. Ta, Y. Inahata, M. Takarada-Iemata, T. Hattori, K. Mori, R. Takahashi, T. Matsuyama, Y. Hayashi, Y. Kitao, and O. Hori. Deletion of Atf6α impairs astroglial activation and enhances neuronal death after brain ischemia in mice., J. Neurochem., 2015, 132, 342-353. Pubmed
2014 S. Ninagawa, T. Okada, Y. Sumitomo, Y. Kamiya, K. Kato, S. Horimoto, T. Ishikawa, S. Takeda, T. Sakuma, T. Yamamoto and K. Mori. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step., J. Cell Biol., 2014, 206, 347-356. Pubmed
2014 Y. Azuma, D. Hagiwara, W. Lu, Y. Morishita, H. Suga, M. Goto, R. Banno, Y. Sugimura, S. Oyadomari, K. Mori, A. Shiota, N. Asai, M. Takahashi, Y. Oiso and H. Arima. Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice., Endocrinol., 2014, 155, 4905-4914. Pubmed
2013 S. Horimoto, S. Ninagawa, T. Okada, H. Koba, T. Sugimoto, Y. Kamiya, K. Kato, S. Takeda and K. Mori. The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein., J. Biol. Chem., 2013, 288, 31517-31527. Pubmed
2013 R. Ozasa, T. Okada, S. Nadanaka, T. Nagamine, A. Zyryanova, H. Harding, D. Ron and K. Mori. The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation., Cell Struct. Funct., 2013, 38, 183-195. Pubmed
2013 T. Ishikawa, T. Okada, T. Ishikawa-Fujiwara, T. Todo, Y. Kamei, S. Shigenobu, M. Tanaka, T. L. Saito, J. Yoshimura, S. Morishita, A. Toyoda, Y. Sakaki, Y. Taniguchi, S. Takeda and K. Mori. ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish, Mol. Biol. Cell, 2013, 24, 1387-1395. Pubmed
2013 L. Zeng, Q. Xiao, M. Chen, A. Margariti, D. Martin, A. Ivetic, H. Xu, J. Mason, W. Wang, G. Cockerill, K. Mori, Y.-S. Li, S. Chien, Y. Hu, and Q. Xu. VEGF-activated XBP1 splicing in endothelial cells is crucial for angiogenesis., Circulation, 2013, 127, 1712-1722. Pubmed
2012 K. Hashida, Y. Kitao, H. Sudo, Y. Awa, K. Mori, R. Takahashi, M. Iinuma, O. Hori. ATF6alpha promotes astroglial activation and neuronal survival in a chronic mouse model of Parkinson’s disease., PLoS One, 2012, 7, e47950. Pubmed
2012 J. M. Lynch, M. Maillet, D. Vanhoutte, A. Schloemer, M. A. Sargent, N. S. Blair, K. A. Lynch, T. Okada, B. J. Aronow, H. Osinska, R. Prywes, J. N. Lorenz, K. Mori, J. Lawler, J. Robbins and J. D. Molkentin. A thrombospondin-dependent pathway for a protective ER stress response, Cell, 2012, 149, 1257-1268. Pubmed
2012 P. Gade, G. Ramachandran, U.B. Maachani, M.A. Rizzo, T. Okada, R. Prywes, A.S. Cross. K. Mori and D. J. Kalvakolanu. A novel IFN-γ-stimulated ATF6/C/EBP-β signaling pathway critical for the expression of DAPK 1 and induction of autophagy., Proc. Natl. Acad. Sci. USA, 2012, 109, 10316-10321. Pubmed
2012 I. V. Aragon, R. A. Barrington, S. Jackowski, K. Mori and J. W. Brewer. The Specialized Unfolded Protein Response of B Lymphocytes: ATF6α-Independent Development of Antibody-Secreting B cells., Mol. Immunol., 2012, 51, 347-355. Pubmed
2012 M. Usui, S. Yamaguchi, Y. Tanji, R. Tominaga, Y. Ishigaki, M. Fukumoto, H. Katagiri, K. Mori, Y. Oka and H. Ishihara. Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance., Metabol., 2012, 61, 1118-1128. Pubmed
2012 P. Menu, A. Mayor, R. Zhou, A. Tardivel, H. Ichijo, K. Mori and J. Tschopp. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway., Cell Death Disease, 2012, 3, e261 Pubmed
2011 T. Ishikawa, Y. Taniguchi, T. Okada, S. Takeda and K. Mori. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in medaka fish., Cell Struc. Func., 2011, 36, 247-259. Pubmed
2011 S. Ninagawa, T. Okada, S. Takeda and K. Mori. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line., Cell Struc. Func., 2011, 36, 187-195. Pubmed
2011 N. Egawa, K. Yamamoto, H. Inoue, R. Hikawa, K. Nishi, K. Mori and R. Takahashi. The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death., J. Biol. Chem., 2011, 286, 7947-7957. Pubmed
2011 Y. Sato, S. Nadanaka, T. Okada, K. Okawa and K. Mori. Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus., Cell Struc. Func., 2011, 36, 35-47. Pubmed
2010 S. Shimasaki, T. Koga, T. Shuto, MA. Suico, T. Sato, K. Watanabe, S. Morino-Koga, M. Taura, S. Okada, K. Mori and H. Kai. Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells., Biochem. Biophys. Res. Commun., 2010, 402, 235-240. Pubmed
2010 K. Yamamoto, K. Takahara, S. Oyadomari, T. Okada, T. Sato, A. Harada and K. Mori. Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress, Mol. Biol. Cell, 2010, 21, 2975-2986. Pubmed
2009 M. Irisawa, J. Inoue, N. Ozawa, K. Mori, and R. Sato. The sterol-sensing ER membrane protein TRC8 hampers ER-to-Golgi transport of SREBP-2/SCAP and reduces SREBP-2 cleavage, J. Biol. Chem., 2009, 284, 28995-29004. Pubmed
2009 A. Uemura, M. Oku, K. Mori, and H. Yoshida. Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during mammalian unfolded protein response, J. Cell Sci., 2009, 122, 2877-2886. Pubmed
2009 L. Zeng, A. Zampetaki, A. Margariti, A. E. Pepe, S. Alam, D. Martin, Q. Xiao, W. Wang, Z. Jin, G. Cockerill, K. Mori, Y. J. Li, Y. Hu, S. Chien and Q. Xu. Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow, Proc. Natl. Acad. Sci. USA, 2009, 106, 8326-8331. Pubmed
2009 A. Tanimura, T. Yujiri, Y. Tanaka, M. Hatanaka, N. Mitani, Y. Nakamura, K. Mori and Y. Tanizawa. The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells, Leukemia Res., 2009, 33, 924-928. Pubmed
2009 H. Yoshida, A. Uemura and K. Mori. pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation, Cell Struc. Func., 2009, 34, 1-10. Pubmed
2009 T. Uemura, T. Sato, T. Aoki, A. Yamamoto, T. Okada, R. Hirai, R. Harada, K. Mori, M. Tagaya, and A. Harada. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival, Mol. Cell. Biol., 2009, 29, 1869-1881. Pubmed
2008 K. Yamamoto, N. Suzuki, T. Wada, T. Okada, H. Yoshida, R. J. Kaufman and K. Mori. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds, J. Biochem., 2008, 144, 477-486 Pubmed
2008 Y. Adachi, K. Yamamoto, T. Okada, H. Yoshida, A. Harada and K. Mori. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum, Cell Struc. Func., 2008, 33, 75-89. Pubmed
2007 K. Yamamoto, T. Sato, T. Matsui, M. Sato, T. Okada, H. Yoshida, A. Harada and K. Mori. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6α and XBP1, Dev. Cell, 2007, 13, 365-376. Pubmed
2007 S. Nadanaka, T. Okada, H. Yoshida, and K. Mori. Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress, Mol. Cell. Biol., 2007, 27, 1027-1043. Pubmed
2007 Y. Tsukumo, A. Tomida, O. Kitahara, Y. Nakamura, S. Asada, K. Mori and T. Tsuruno. Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation, J. Biol. Chem., 2007, 282, 29264-29272. Pubmed
2006 H. Yoshida, S. Nadanaka, R. Sato and K. Mori. XBP1 is critical to protect cells from endoplasmic reticulum stress: Evidence from site-2 protease-deficient Chinese hamster ovary cells, Cell Struc. Funct., 2006, 31, 117-125. Pubmed
2006 M. Arai, N. Kondoh, N. Imazeki, A. Hada, K. Hatsuse, F. Kimura, O. Matsubara, K. Mori, T. Wakatsuki, M. Yamamoto. Transformation-associated gene regulation by ATF6α during hepatocarcinogenesis, FEBS lett., 2006, 580, 184-190. Pubmed
2006 S. Nadanaka, H. Yoshida and K. Mori. Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation, Cell Struc. Func., 2006, 31, 127-134. Pubmed
2006 H. Yoshida, M. Oku, M. Suzuki and K. Mori. pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response, J. Cell Biol., 2006, 172, 565-575. Pubmed
2006 K. Zu, T. Bihani, A.Lin,Y.-M. Park, K. Mori, and C. Ip. Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells, Oncogene, 2006, 25, 546-554. Pubmed
2006 Y. Oda, T. Okada, H. Yoshida, R. J. Kaufman, K. Nagata and K. Mori. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation, J. Cell Biol., 2006, 172, 383-393. Pubmed
2006 S. Nadanaka, H. Yoshida, R. Sato and K. Mori. Analysis of ATF6 activation in site-2 protease-deficient Chinese hamster ovary cells, Cell Struc. Funct., 2006, 31, 109-116. Pubmed
2006 D.T. Rutkowski, S.M. Arnold, C.N. Miller, J. Wu, J. Li, K.M. Gunnison, K. Mori, A.A. Sadighi Akha, D. Raden and R.J. Kaufman. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins, PLoS Biol., 2006, 4, 2024-2041. Pubmed
2005 X. Xue, J.H. Piao, A. Nakajima, S. Sakon-Komazawa, Y. Kojima, K. Mori, H. Yagita, K. Okumura, H. Harding, H. Nakano. Tumor necrosis factor α (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα, J. Biol. Chem., 2005, 280, 33917-33925. Pubmed
2005 J. Ramos-Castaeda, Y.-N. Park, M. Liu, K. Hauser, H. Rudolph, G.E. Shull, M. F. Jonkman, K. Mori, S. Ikeda, H. Ogawa, and P. Arvan. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress, J. Biol. Chem., 2005, 280, 9467-9473. Pubmed
2005 Z.-M. Huang, T. Tan, H. Yoshida, K. Mori, Y. Ma, and T.S.B. Yen. Activation of Hepatitis B Virus S promoter by a cell-type restricted IRE1-dependent pathway induced by endoplasmic reticulum stress, Mol. Cell. Biol., 2005, 25, 7522-7533. Pubmed
2004 M. M. Khan, T. Nomura, T. Chiba, K. Tanaka, H. Yoshida, K. Mori, and S. Ishii. The fusion oncoprotein PML-RARa induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress, J. Biol. Chem., 2004, 279, 11814-11824 Pubmed
2004 L. Zeng, M. Lu, K. Mori, S. Luo, A.S. Lee, Y. Zhu, and J. Y-J. Shyy. Activating transcription factor 6 modulates the sterol regulatory element binding protein-mediated lipogenesis, EMBO J., 2004, 23, 950-958. Pubmed
2004 J. Nozaki, H. Kubota, H. Yoshida, M. Naitoh, J. Goji, T. Yoshinaga, K. Mori, A. Koizumi, and K. Nagata. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic β cells, Genes Cells, 2004, 9, 261-270. Pubmed
2004 K. D. Tardif, K. Mori, R. J. Kaufman, and A. Siddiqui. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response, J. Biol. Chem., 2004, 279, 17158-17164. Pubmed
2004 M. Flores-Diaz, J.-C. Higuita, I. Florin, T. Okada, P. Pollesello, T. Bergman, M. Thelestam, K. Mori, and A. Alape-Giron. A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen regulated proteins independent of the endoplasmic reticulum stress elements, J. Biol. Chem., 2004, 279, 21724-21731. Pubmed
2004 K. E. Gunn, N. M. Gifford, K. Mori, and J. W. Brewer. A role for the unfolded protein response in optimizing antibody secretion, Mol. Immunol., 2004, 41, 919-927. Pubmed
2004 K. Yamamoto, H. Yoshida, K. Kokame, R. J. Kaufman, and K. Mori. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II, J. Biochem., 2004, 136, 343-350 Pubmed
2004 L. Romero-Ramirez, H. Cao, D. Nelson, E. Hammond, A.-H. Lee, H. Yoshida, K. Mori, L. H. Glimcher, N. C. Denko, A. J. Giaccia, Q.-T. Le, and A. C. Koong. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth, Cancer Res., 2004, 64, 5943-5947. Pubmed
2004 R. Sriburi, S. Jackowski, K. Mori, and J. W. Brewer. XBP1: a link between the unfolded protein response, lipid biosynthesis and biogenesis of the endoplasmic reticulum, J. Cell Biol., 2004, 167, 35-41. Pubmed
2004 N. Ogawa and K. Mori. Autoregulation of the HAC1 gene is required for sustained activation of the yeast unfolded protein response, Genes Cells, 2004, 9, 95-104. Pubmed
2004 S. Nadanaka, H. Yoshida, F. Kano, M. Murata, and K. Mori. Activation of mammalian unfolded protein response is compatible with the quality control system operating in the endoplasmic reticulum, Mol. Biol. Cell, 2004, 15, 2537-2548. Pubmed
2003 R. Kumar, G. S. Krause, H. Yoshida, K. Mori, and D. J. DeGracia. Dysfunction of the unfolded protein response during global brain ischemia and reperfusion, J. Cereb. Blood Flow Metab., 2003, 23, 462-471. Pubmed
2003 H. Yoshida, T. Matsui, N. Hosokawa, R. J. Kaufman, K. Nagata, and K. Mori. A time-dependent phase shift in the mammalian unfolded protein response, Dev. Cell, 2003, 4, 265-271. Pubmed
2003 B. Nyfeler, O. Nufer, T. Matsui, K. Mori and H.-P. Hauri. The cargo receptor ERGIC-53 is a target of the unfolded protein response, Biochem. Biophys. Res. Commun., 2003, 304, 599-604. Pubmed
2003 M. Shuda, N. Kondoh, N. Imazeki, K. Tanaka, T. Okada, K. Mori, A. Hada, M. Arai, T. Wakatsuki, O. Matsubara, N. Yamamoto, M. Yamamoto. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis, J. Hepatol., 2003, 38, 605-614. Pubmed
2003 T. Okada, K. Haze, S. Nadanaka, H. Yoshida, N. G. Seidah, Y. Hirano, R. Sato, M. Negishi and K. Mori. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6, J. Biol. Chem., 2003, 278, 31024-31032 Pubmed
2002 T. Gotoh, S. Oyadomari, K. Mori, and M. Mori. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP, J. Biol. Chem., 2002, 277, 12343-12350. Pubmed
2002 K. Lee, W. Tirasophon, X. Shen, M. Michalak, R. Prywes, T. Okada, H.Yoshida, K. Mori, and R. J. Kaufman. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response, Genes Dev., 2002, 16, 452-466. Pubmed
2002 K. D. Tardif, K. Mori, and A. Siddiqui. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway, J. Virol., 2002, 76, 7453-7459. Pubmed
2002 T. Okada, H. Yoshida, R. Akazawa, M. Negishi, and K. Mori. Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response, Biochem. J., 2002, 366, 585-594. Pubmed
2001 H.Yoshida, T.Matsui, A.Yamamoto, T.Okada, and K.Mori. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor, Cell, 2001, 107, 881-891. Pubmed
2001 K. Haze, T. Okada, H. Yoshida, H. Yanagi, T. Yura, M. Negishi, and K. Mori. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response, Biochem. J., 2001, 355, 19-28. Pubmed
2001 H. Yoshida, T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi and K. Mori. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6a and 6b that activates the mammalian unfolded protein response, Mol. Cell. Biol., 2001, 21, 1239-1248. Pubmed
2001 Katayama, T., Imaizumi, K., Honda, A., Yoneda, T., Kudo, T., Takeda, M., Mori K., Rozmahel, R., Fraser, P., St George-Hyslop, P.,and Tohyama, M. Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer’s disease-linked presenilin 1 mutations, J. Biol. Chem., 2001, 276, 43446-43454. Pubmed
2001 X. Shen, R.E. Ellis, K. Lee, C.-Y. Liu, K. Yang, A. Solomon, H. Yoshida, R. Morimoto, D.M. Kurnit, K. Mori, and R.J. Kaufman. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development, Cell, 2001, 107, 893-903. Pubmed
2000 K. Mori, N. Ogawa, T. Kawahara, H. Yanagi, T. Yura. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response, Proc. Natl. Acad. Sci. USA, 2000, 97, 4660-4665. Pubmed
2000 H. Yoshida, T. Okada, K. Haze, H. Yanagi, T. Yura, M. Negishi and K. Mori. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response, Mol. Cell. Biol., 2000, 20, 6755-6767. Pubmed
1999 K. Haze, H. Yoshida, H. Yanagi, T. Yura, and K. Mori. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress, Mol. Biol. Cell, 1999, 10, 3787-3799. Pubmed
1998 T. Kawahara, H. Yanagi, T. Yura, and K. Mori. Unconventional splicing of HAC1/ERN4 mRNA required for the unfolded protein response: sequence-specific and non-sequential cleavage of the splice sites, J. Biol. Chem., 1998, 273, 1802-1807. Pubmed
1998 K. Mori, N. Ogawa, T. Kawahara, H. Yanagi, and T. Yura. Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiae, J. Biol. Chem., 1998, 273, 9912-9920. Pubmed
1998 H. Yoshida, K. Haze, H. Yanagi, T. Yura, and K. Mori. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic leucine zipper transcription factors, J. Biol. Chem., 1998, 273, 33741-33749. Pubmed
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邦文総説 (24)

論文 リンク
2009 森 和俊. 用語解説「小胞体ストレス」, 分子細胞治療, 2009, 8, 472-475.
2007 遠藤斗志也、森 和俊、田口英樹編集. タンパク質の一生集中マスター, 羊土社, 2007,
2005 森 和俊企画. 特集「波及する小胞体ストレスの概念」, 実験医学, 2005, 11月号
2005 小田裕香子,森, 和俊. 小胞体ストレス応答によって制御されるDerlins, 実験医学, 2005, 23, 135-141.
2005 森, 和俊. 小胞体ストレスの概念と小胞体ストレス応答の分子機構, 実験医学, 2005, 23, 2760-2765.
2004 小椋 光、遠藤斗志也、森 正敬、吉田賢右編集. 「細胞における蛋白質の一生」生成・成熟・輸送・管理・分解・病態, 蛋白質核酸酵素, 2004, 5月号増刊
2004 森, 和俊. 蛋白質品質管理機構としてのUPR, 蛋白質核酸酵素, 2004, 49, 992-997.
2003 森, 和俊, 灘中里美. 膜結合性転写因子の細胞内トラフィック, 生化学, 2003, 75, 506-511.
2002 吉田秀郎, 森, 和俊. unfolded protein response を制御する遺伝子群, 遺伝子医学, 2002, 6, 130-134.
2002 吉田秀郎, 森, 和俊. スプライソソーム非依存型mRNAスプライシングシステムの高等動物基質の発見と小胞体ストレス応答における意義, 細胞工学, 2002, 21, 302-303.
2002 森, 和俊. 小胞体におけるタンパク質の品質管理とUPR, 細胞工学, 2002, 21, 364-367.
2002 岡田徹也,森, 和俊. 小胞体ストレスに応答して活性化される転写因子, 脳21, 2002, 5, 121-125.
2002 森, 和俊, 吉田秀郎. フレームスイッチ型スプライシング−新しいタンパク質の活性制御機構, 実験医学, 2002, 20, 1000-1004.
2001 永田和宏、森 正敬、吉田賢右共編. 「分子シャペロンによる細胞機能制御」- 真核細胞のストレス応答と分子シャペロン, シュプリンガー・フェアラーク東京, 2001, 第3章2項
2001 森, 和俊. 小胞体から核への情報伝達機構, 細胞, 2001, 33, 169-172.
2000 森 和俊. 「バイオサイエンスの新世紀」  第2巻 タンパク質の一生, 日本生化学会編集, 2000, 第11章 品質管理
1999 森, 和俊. UPR (unfolded protein response) 経路を介した小胞体ストレス応答, 蛋白質核酸酵素, 1999, 44, 2442-2448.
1999 森, 和俊. タンパク質のフォールディングと小胞体−核間情報輸送, 実験医学, 1999, 17, 2399-2404.
1998 森, 和俊. 小胞体から核への細胞内情報伝達機構 unfolded protein response の解析, 生化学, 1998, 70, 505-515.
1994 森, 和俊. 小胞体から核への情報伝達におけるセンサー Ern1p, 実験医学, 1994, 12, 548-551.
1994 森, 和俊. BiP の誘導機構ー小胞体から核への情報伝達ー, 蛋白質核酸酵素, 1994, 39, 828-836.
1994 森, 和俊. 酵母小胞体内腔のストレスタンパク質とその誘導, 生化学, 1994, 66, 1519-1523.
1994 森, 和俊. グルコース調節蛋白質 (GRP) とストレス応答, 最新医学, 1994, 49, 2077-2083.
1993 森, 和俊. 小胞体から核への情報伝達にもリン酸化が関与, 実験医学, 1993, 11, 819-821.


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